Dr Elizabeth Walden

Lecturer in Biomedical Science

Three Counties Medical School

MBChB

Contact Details

Elizabeth is exited to become a lecturer here at the University of Worcester in the TCMS. She is a biochemist by training and looks forward to applying her cell biology understanding of disease to a more wholistic understanding of medicine through teaching in the TCMS.

Prior to joining Worcester, Elizabeth worked within medical schools on the research side, specifically on basic cellular processes in mammalian and fungal cells. Her MSc research was on DNA damage and the DNA damage repair and response pathways. Her PhD research focused on metabolic regulation in the cell. Specifically, how the NuA4 (AKA Tip60) complex, a lysine acetyltransferase, plays an important role in the regulation of mitochondrial structure and function, glycogen storage, and lipid composition.

Qualifications

PhD in Biochemistry University of Ottawa
MSc in Biochemistry University of Western Ontario
BEd Queen’s University Canada
BSc Trent University

Research Interests

Biochemistry, understanding cell signalling
Regulation of cellular processes.

Recent Publications

Pham, T., Walden, E., Huard, S., Pezacki, J., Fullerton, M.D., and Baetz, K. Fine-tuning acetyl-CoA carboxylase 1 activity through localization: functional genomics reveals a role for the lysine acetyltransferase NuA4 and sphingolipid metabolism in regulating Acc1 activity and localization. Genetics. 2022 Jul 30;221(4): iyac086. *Co-First Authors

Mercurio, K., Singh, D., Walden, E.A., and Baetz, K. Global analysis of Saccharomyces cerevisiae growth in mucin. G3. 2021 Oct 19;11(11).

Fletcher, E., Mercurio, K., Walden, E.A., and Baetz, K. A yeast chemogenomic screen identifies pathways that modulate adipic acid toxicity. iScience. 2021 Mar 18;24(4).

Walden, E.A., Fong, R.Y., Pham, T., Knill, H., Laframboise, S.J., Huard, S., Harper, M-E., Baetz, K. Phenomic screen identifies a role for yeast lysine acetyltransferase NuA4 in the control of Bcy1 subcellular localization, glycogen biosynthesis, and mitochondrial morphology. PLOS Genetics. 2020;16(11).

Fell, V.L., Walden, E.A., Hoffer, S.M., Rogers, S.R., Aitken, A.S., Salemi, L.M., and Schild-Poulter, C. Ku70 Serine-155 mediates Aurora B inhibition and activation of the DNA damage response. Sci Rep. 2016 Nov 16; 6:37194.